We are interested in understanding how memories are acquired, stored, and lost in the brain under normal and pathological conditions. Our approach spans from investigating circuit reorganization across the entire brain to probing the dynamics of individual synapses at the single-neuron level.
We use two and three-photon in-vivo imaging, behavioral, and pharmacological approaches to investigate
- mechanisms of memory deficit in mouse models of Alzheimer’s disease
- mechanisms of natural forgetting of a visual recognition memory
- relationship between aberrant neural activity and synaptic deficits in Alzheimer’s disease
- the role of mitochondria in synaptic plasticity and learning
- mitochondrial impairments in mouse models of Alzheimer’s disease
- brain-wide synaptic and cellular correlates of visual experience