We are interested in understanding how memories are acquired, stored, and lost in the brain under normal and pathological conditions. We approach these questions at the level of the entire brain to uncover circuit reorganization and at the level of single neurons to probe the dynamics of individual synapses.
We use state of the art multi-photon in-vivo imaging, behavioral, and pharmacological approaches to investigate
- mechanisms of memory deficit in mouse models of Alzheimer’s disease
- mechanisms of natural forgetting of a visual recognition memory
- the disruption of excitation-inhibition balance in mouse models of Alzheimer’s disease
- mitochondrial impairments in mouse models of Alzheimer’s disease
- brain-wide synaptic and cellular correlates of visual experience