We are interested in understanding how memories are acquired, stored and lost in the brain under normal and pathological conditions. We approach these questions both at the level of the entire brain to uncover circuit reorganization and at the level of single neurons to probe the dynamics of individual synapses.
We use state of the art multi-photon in-vivo imaging approaches to investigate:
- the changes to functional connectivity between brain regions associated with memory storage
- the role of quiescent neurons in memory storage
- the mechanisms by which excitation-inhibition imbalance disrupts memory
- the disruption of excitation-inhibition balance in mouse models of Alzheimer’s disease
- how excitatory synapses are lost in mouse models of Alzheimer’s disease